Material Safety Data Sheet: Ethyl 2-Bromopropionate

Identification

Product Name: Ethyl 2-Bromopropionate
Chemical Formula: C5H9BrO2
CAS Number: 535-11-5
Synonyms: Ethyl alpha-bromopropionate, Ethyl 2-bromopropanoate
Recommended Use: Laboratory chemicals, synthesis intermediate
Restrictions on Use: Not for food, drug, or household use
Manufacturer: Supplier details and emergency phone contact must be obtained from certified distributor
Emergency Contact: ChemTrec (24-hour) or regional poison control center
Product Codes: Available upon request from supplier documentation

Hazard Identification

Classification (GHS): Flammable liquid (Category 3), Acute toxicity oral (Category 4), Skin irritation (Category 2), Eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: May cause skin irritation, causes serious eye irritation, harmful if swallowed, flammable liquid and vapor
Pictograms: Flame symbol, exclamation mark
Routes of Exposure: Inhalation, ingestion, skin or eye contact
Target Organs: Eyes, skin, respiratory system
Precautionary Statements: Wear protective gloves and eye protection, keep away from heat and open flames, avoid breathing mist or vapor, wash hands thoroughly after handling, use only with adequate ventilation

Composition / Information on Ingredients

Chemical Name: Ethyl 2-Bromopropionate
CAS Number: 535-11-5
Concentration: 97–100%
Impurities: Typically meets purity standards for laboratory reagent grade
Other Ingredients: Trace residues may include unreacted alcohols or bromide ions, not present in significant concentrations

First Aid Measures

Inhalation: Move affected person to fresh air, keep comfortable for breathing, seek medical attention if any symptoms persist, avoid self-exposure, offer oxygen if short of breath
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes, wash affected area with non-abrasive soap, seek medical attention if irritation or discomfort continues
Eye Contact: Immediately flush eyes with plenty of water for a minimum of 15 minutes, lift eyelids occasionally, remove contact lenses if present and easy to do, consult a medical professional promptly
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, never offer anything by mouth to an unconscious individual, seek immediate medical advice
Most Important Symptoms: Redness or irritation of the skin and eyes, coughing, difficulty breathing, abdominal discomfort, no known delayed or chronic symptoms at low exposure but high-dose exposure may increase risk of respiratory or central nervous system effects

Fire-Fighting Measures

Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Media: Do not use direct water jets; spattering may occur
Specific Hazards During Fire: May emit hydrogen bromide, carbon oxides under combustion, volatile organic vapors
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Firefighting Procedures: Cool containers with water spray from a safe distance, move containers away from fire if possible, isolate hazard area, ventilate before entering, avoid inhaling fumes
Explosion Hazard: Vapors may form explosive mixtures with air under certain conditions, take precautions for static discharge

Accidental Release Measures

Personal Precautions: Evacuate area, ensure adequate ventilation, avoid breathing vapors, wear chemically resistant gloves, lab coat, and eye/face protection
Environmental Precautions: Prevent entry into drains, surface water, or soil, contain spill if possible
Methods for Containment: Dike with inert absorbent (e.g., vermiculite, sand), prevent spread of liquid
Methods for Cleanup: Use non-sparking tools, absorb spillage with approved material, collect in suitable waste container for disposal, ventilate area, decontaminate surfaces using compatible cleaning agent
Secondary Measures: Notify authorities if large spills impact local environment or water systems

Handling and Storage

Safe Handling: Use only in fume hoods or well-ventilated areas, use appropriate personal protective equipment, avoid contact with skin, eyes, or clothing, do not breathe vapors
Hygiene Practices: Wash hands and face after handling, remove and wash contaminated clothing before reuse, eat or drink only in designated clean areas
Storage Conditions: Store tightly closed in cool, dry, well-ventilated area, away from direct sunlight and incompatible materials, segregate from oxidizers, acids, and combustibles
Container Requirements: Use original or approved containers with proper hazard labeling
Special Considerations: Keep away from ignition sources, install grounding and bonding for bulk transfer

Exposure Controls and Personal Protection

Exposure Limits: No established OSHA PEL or ACGIH TLV for this compound, minimize exposure using best industrial hygiene practices
Engineering Controls: Work in fume hood or with local exhaust, install spill containment if used in larger quantities
Personal Protection: Wear chemical safety goggles, body-covering clothing, gloves rated for brominated organics, face shield for splash risk
Respiratory Protection: NIOSH-approved organic vapor respirator if ventilation inadequate or concentration exceeds safe levels
Environmental Controls: Prevent emissions to air, water, soil, use closed systems if possible

Physical and Chemical Properties

Appearance: Clear colorless to light yellow liquid
Odor: Slightly sweet, characteristic ester smell
Odor Threshold: Not established
pH: Not applicable (non-aqueous)
Melting Point/Freezing Point: -60 °C (approximate)
Boiling Point/Range: 151–154 °C
Flash Point: 47 °C (closed cup)
Evaporation Rate: Not rapid, slower than water
Flammability (Solid, Gas): Flammable liquid
Vapor Pressure: 3 mmHg at 25 °C
Vapor Density: ~4.6 (air = 1)
Relative Density: 1.4–1.5 (water = 1)
Solubility: Slightly soluble in water, miscible with most organic solvents
Partition Coefficient (n-octanol/water): Data not widely available, likely moderate
Auto-ignition Temperature: No data
Decomposition Temperature: Not determined; thermally unstable above boiling
Viscosity: Low viscosity liquid

Stability and Reactivity

Chemical Stability: Stable under standard temperatures and pressures for storage, gradual hydrolysis may occur in moist air
Reactivity: Reacts with strong oxidizers, bases, ceases to be stable under strong heat or light
Thermal Decomposition: Produces toxic fumes including hydrogen bromide, carbon monoxide
Hazardous Polymerization: Polymerization does not occur under normal conditions
Avoid: Strong acids and bases, oxidizing agents, direct sunlight
Incompatibilities: Alkali metals, strong reducing agents, finely divided metals may react vigorously

Toxicological Information

Likely Routes of Exposure: Inhalation, skin or eye absorption, accidental ingestion
Acute Toxicity: Oral LD₅₀ (rat): 940 mg/kg, inhalation and dermal data not complete but may irritate tissues
Skin Irritation: Causes redness and burns on direct contact
Eye Damage: Provokes redness, severe irritation, possible temporary vision disturbance
Respiratory Effects: Inhalation produces coughing, respiratory tract irritation
Chronic Toxicity: Data lacking; long-term health impacts not well documented due to limited use outside laboratory
Carcinogenicity: Not classified by IARC, NTP, or OSHA as carcinogenic
Mutagenicity/Teratogenicity: No studies showing genetic or developmental hazard
Symptoms: Headache, nausea, dizziness at high concentrations

Ecological Information

Toxicity to Aquatic Life: Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Does not easily biodegrade, hydrolysis is slow in natural waters, product remains for extended periods
Bioaccumulation Potential: Potential not well studied, possible moderate risk due to organic structure
Mobility in Soil: Leaches slightly; not very mobile due to limited water solubility
Other Adverse Effects: Volatile organic compound, may contribute to smog if released on a large scale
Ozone Depletion: Not known to impact ozone layer

Disposal Considerations

Waste Disposal Methods: Dispose of through a licensed chemical waste contractor, incineration at approved facility preferred, neutralize under expert supervision
Container Disposal: Rinse thoroughly, label as hazardous, ship for proper recycling or disposal
Regulatory Requirements: Observe all federal, state, and local environmental regulations
Special Instructions: Do not pour into drains or general waste; separate from incompatible materials before disposal

Transport Information

UN Number: UN 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (Ethyl 2-bromopropionate)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Labels: Flammable liquid
Environmental Hazards: Hazard to aquatic environment
Special Precautions: Secure containers upright, prevent leaks, carry spill kits during transportation, follow ICAO/IATA/IMDG transport regulations

Regulatory Information

TSCA: Listed on US Toxic Substances Control Act Inventory
DSL/NDSL (Canada): Listed/Compliant
EINECS/ELINCS (Europe): 208-613-9
REACH (EU): Not pre-registered, use for research or production requires compliance with relevant regulations
SARA Title III (Sections 302, 311/312, 313): Not listed as an extremely hazardous substance; applicable as a hazardous chemical for reporting purposes
California Proposition 65: Not listed
Other Regulation: Users must comply with national workplace, environmental, and transport laws; specific employee training recommended
Labeling Requirements: Bottle and packaging require hazard and precautionary statements as defined by GHS